Scientific Publications by FDA Staff

J Clin Pharmacol 2016 Jun;56(6):733-9

Prediction of drug clearance in premature and mature neonates, infants and children less than or equal to 2 years of age: a comparison of the predictive.

Mahmood I

The objective of this study was to evaluate the predictive performance of four allometric models to predict clearance in pediatrics age ranging from premature neonates to children of /=50% in approximately 30% of the children by the proposed three methods and 73% by exponent 0.75. The three new proposed allometric models can predict mean clearances of drugs in children from premature neonates to