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Cytokine Growth Factor Rev 2016 Oct;31:37-48

The role of adiponectin in obesity-associated female-specific carcinogenesis.

Nagaraju GP, Rajitha B, Aliya S, Kotipatruni RP, Madanraj AS, Hammond A, Park D, Chigurupati S, Alam A, Pattnaik S

Abstract

Adipose tissue is a highly vascularized endocrine organ, and its secretion profiles may vary with obesity. Adiponectin is secreted by adipocytes that make up adipose tissue. Worldwide, obesity has been designated a serious health problem among women and is associated with a variety of metabolic disorders and an increased risk of developing cancer of the cervix, ovaries, uterus (uterine/endometrial), and breast. In this review, the potential link between obesity and female-specific malignancies is comprehensively presented by discussing significant features of the intriguing and complex molecule, adiponectin, with a focus on recent findings highlighting its molecular mechanism of action in female-specific carcinogenesis.

Category: Journal Article
PubMed ID: #27079372 DOI: 10.1016/j.cytogfr.2016.03.014
Includes FDA Authors from Scientific Area(s): Regulatory Affairs
Entry Created: 2016-04-16 Entry Last Modified: 2016-11-12
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