Scientific Publications by FDA Staff

Clin J Pain 2017 May;33(5):452-61

Trends in the nonmedical use of OxyContin, United States, 2006-2013.

Jones CM, Muhuri PK, Lurie PG

OBJECTIVES: The role of the opioid OxyContin in the opioid abuse epidemic has been well-documented. In 2010, OxyContin was reformulated to make it more difficult to abuse. We assessed past-year OxyContin nonmedical use among a nationally representative population and among nonmedical users of opioid pain relievers in the United States between 2006 and 2013. METHODS: Data are from the National Survey on Drug Use and Health. Prevalence estimates of past-year OxyContin nonmedical use overall and by sociodemographic, geographic, and substance use characteristics were calculated for each year, 2006 through 2013. Multivariable logistic regression was used to identify individual characteristics associated with past-year OxyContin nonmedical use prior to and after reformulation. RESULTS: The prevalence of past-year nonmedical use of OxyContin among people 12 years and older in the U.S. was 0.5%. This was significantly lower than the prevalence in 2010 (0.7%; P<0.05), and was similar to that in 2006-2009 and 2011-2012. Among past-year nonmedical users of pain relievers in 2013, the prevalence of OxyContin nonmedical use was 13.0%. This was significantly higher than the prevalence in 2006 (10.5%; P<0.05), and was similar to that in 2007 through 2012. Groups with increased odds of using OxyContin nonmedically in the past-year were similar prior to and after reformulation. Odds for past-year OxyContin nonmedical use after reformulation were greatest for: people reporting >/=200 days of pain reliever nonmedical use, aOR=3.61 (95% CI, 2.47-5.28); past-year heroin users, aOR=3.45 (95% CI, 2.22-5.37); and people with past-year pain reliever abuse or dependence, aOR=2.57 (95% CI, 1.88-3.51). DISCUSSION: The prevalence of past-year OxyContin nonmedical use in 2013, three years after reformulation, was significantly lower than the prevalence in the reformulation year, but similar to other years before and after reformulation. The prevalence of OxyContin nonmedical use among nonmedical users of pain relievers was higher than or similar to historical prevalence rates prior to reformulation. Groups with increased odds of OxyContin nonmedical use were similar prior to and after reformulation.