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CPT Pharmacometrics Syst Pharmacol 2016 Sep;5(9):452-4

Commentary on: "Levofloxacin-Induced QTc Prolongation Depends on the Time of Drug Administration".

Garnett C, Johannesen L

Abstract

Circadian variations in the corrected QT (QTc) interval have been documented in clinical trials. Animal models show circadian variations in expression of the cardiac ion channels that are necessary to maintain the heart's electrophysiological properties. Can these diurnal rhythms in QTc affect the ability of a drug to delay cardiac repolarization?

Category: Journal Article, Editorial
PubMed ID: #27647678 DOI: 10.1002/psp4.12128
PubMed Central ID: #PMC5036419
Includes FDA Authors from Scientific Area(s): Drugs
Entry Created: 2016-09-21 Entry Last Modified: 2017-05-23
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