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J Clin Pharmacol 2017 Apr;57(4):476-83

Prediction of clearance in neonates and infants (less than or equals to 3 months of age) for drugs which are glucuronidated: a comparative study between allometric scaling and physiologically based pharmacokinetic modeling.

Mahmod I, Ahmad T, Mansoor N, Sharib SM

Abstract

The objective of this study was to evaluate the predictive performances of allometric models and a physiologically based pharmacokinetic model (PBPK) to predict clearance of glucuronidated drugs in neonates (

Category: Journal Article
PubMed ID: #27704554 DOI: 10.1002/jcph.837
Includes FDA Authors from Scientific Area(s): Biologics
Entry Created: 2016-10-06 Entry Last Modified: 2017-05-11
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