Scientific Publications by FDA Staff

MAGMA 2019 Feb;32(1):15-23

Improvement of 19F MR image uniformity in a mouse model of cellular therapy using inductive coupling.

Park BS, Ma G, Koch WT, Rajan SS, Mastromanolis M, Lam J, Sung K, McCright B

OBJECT: Improve 19F Magnetic Resonance Imaging uniformity of perfluorocarbon (PFC) labeled cells by using a secondary inductive resonator tuned to 287 MHz to enhance the induced radio frequency (RF) magnetic field (B1) at 7.0T. MATERIALS AND METHODS: Following Faraday’s induction law, the sign of induced B1 made by the secondary resonator can be changed depending on the tuning of the resonator. A secondary resonator located opposite side of the phantom of the 19F surface coil can be shown to enhance or subtract the induced B1 field, depending upon its tuning. RESULTS: The numerical simulation results of rotating transmit B1 magnitude (|B1+|) and corresponding experimental 19F images were compared without and with the secondary resonator. With the secondary resonator tuned to 287 MHz, improvements of |B1+| and 19F image uniformity were demonstrated. The use of the secondary resonator improved our ability to visualize transplanted cell location and survival non-invasively over a period of 6 weeks. CONCLUSION: The secondary resonator tuned to enhance the induced B1 results in improved image uniformity and sensitivity in a pre-clinical application, cell tracking of PFC labeled cells with the secondary resonator.