Scientific Publications by FDA Staff

Retrovirology 2004 Oct 29;1(1):35

Within you, without you: HIV-1 Rev and RNA export.

Dayton AI

Nucleo-cytoplasmic transport of RNA is one of many cellular pathways whose illumination has progressed hand in hand with understanding of retroviral mechanisms. A recent paper in Cell reports the involvement of an RNA helicase in the pathway by which HIV exports partially spliced and unspliced RNA out of the nucleus. This suggests the ubiquity of RNA helicases in RNA export from the nucleus, and has novel mechanistic implications.