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U.S. Department of Health and Human Services

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Title:  Effect of temperature and diet composition on residue depletion of oxytretracycline in cultured channel catfish.
 
Authors:  Luzzana U, Serrini G, Moretti VM, Maggi GL, Valfre F, Polidori P
 
Drug:  Oxytetracycline
 
Fish species:  Catfish, channel
 
Date:  1994
 
Sample:  muscle
 
Ave Weight (gm):  945
 
Ave Water temp (°C):  18
 
Water:  Freshwater
 
Dosage:  7500 mg/kg 7d
 
Route:  PO
 
Comments:  Three diet compositions tested (control diet = CD, high energy high protein = HEP, high energy high lipid=HEL) at two different water temperatures (18C, 23C). Oxytetracycline residue concentration (ug/kg) CD at 18C: 1d post-dose=58.3, 3d post-dose=38.5, 8d post-dose=16.1, 13d post-dose=10.3, 18d post-dose=not detected (nd). Oxytetracycline residue concentration (ug/kg) HEP at 18C: 1d post-dose=63.2, 3d post-dose=35.4, 8d post-dose=nd, 13d post-dose=nd, 18d post-dose=nd. Oxytetracycline residue (ug/kg) concentration HEL at 18C: 1d post-dose=95.0, 3d post-dose=49.1, 8d post-dose=11.1, 13d post-dose=11.0, 18d post-dose= nd. Effects of diet on oxytetracycline absorption, metabolism and excretion in channel catfish are significant at 18C and no statistically significant differences found at 23C.
 
Citation:  Analyst 119:2757-2759
 
Link:  http://www.ncbi.nlm.nih.gov/pubmed/7879890  Opens a new window
 
Genus Species:  Ictalurus punctatus
 
Drug Class:  Antibiotic-Tetracycline
 
Wt gm-detail:  945+/- 173g
 
Water temp (°C)-detail:  18C (Range: 16.9-18.9)
 
Dosage-detail:  7500 mg/kg 7d
 
Method:  HPLC
 
Authors-red:  Luzzana U, Serrini G, Moretti VM, Maggi GL, Valfre F, Polidori P
 
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