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U.S. Department of Health and Human Services

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Title:  Tissue levels of oxolinic acid after oral and intravascular administration to freshwater and seawater rainbow trout.
 
Authors:  Ishida N
 
Drug:  Oxolinic acid
 
Fish species:  Trout, rainbow
 
Date:  1992
 
t1/2-hr:  24
 
est:  est
 
Sample:  blood, serum
 
Ave Weight (gm):  472
 
Ave Water temp (°C):  15
 
Water:  Saltwater
 
Dosage:  20 mg/kg sd
 
Route:  IV
 
Comments:  Fish acclimated in seawater 6 months. Serum levels were barely detectable by 144h vs 244 h of the freshwater group. Residues 0.5h=13.8, 3h=8.0, 24h=0.92, 72h=0.62, 144h=0.04ug/ml. No statistical difference from red sea bream held in seawater. Drug given under MS222. Glucuronide metabolites in bile of both salt and freshwater groups.
 
Citation:  Aquaculture 102:9-15
 
Link:  http://dx.doi.org/10.1016/0044-8486(92)90284-R  Opens a new window
 
Genus Species:  Oncorhynchus mykiss
 
Drug Class:  Antibiotic-Quinolone
 
t1/2-detail:  < 24 h est
 
Wt gm-detail:  472 g
 
Water temp (°C)-detail:  15 C
 
Dosage-detail:  20 mg/kg sd
 
Method:  HPLC
 
Authors-red:  Ishida N
 
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