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Title:
Pharmacokinetics, tissue distribution, and metabolism of nitrofurantoin in the channel catfish (Ictalurus punctatus).
Authors:
Stehly GR, Plakas SM (1993)
Drug:
Nitrofurantoin
Fish species:
Catfish, channel
Date:
1993
t1/2-hr:
5
est:
est
Sample:
blood, plasma
Ave Weight (gm):
700
Ave Water temp (°C):
25
Water:
Freshwater
Dosage:
1 mg/kg sd
Route:
PO
Comments:
14C-Nitrofurantoin. Urinary catheterized fish. Peak plasm conc 0.06 ug/ml at 2 h. Bioav. 17%, absorption t 1/2 1.04h. Total residue ug/g 4h=1.2, 1d=0.5, 2d=0.4, 3d=0.24. t1/2 est from graph.
Metabolites:
5 metabolites
Citation:
Aquaculture 113:1-10
Link:
http://dx.doi.org/10.1016/0044-8486(93)90335-V
Genus Species:
Ictalurus punctatus
Drug Class:
Antibiotic-Furan
t1/2-detail:
5 h estimate from graph
Wt gm-detail:
0.4-1.0 kg
Water temp (°C)-detail:
25 C
Dosage-detail:
1 mg/kg sd
Method:
HPLC-Rad
Authors-red:
Stehly GR, Plakas SM (1993)
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