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U.S. Department of Health and Human Services

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Title:  Pharmacokinetics of sulphamonomethoxine and sulphadimethoxine following oral administration to cultured rainbow trout (Oncorhynchus mykiss).
 
Authors:  Uno K, Aoki T, Ueno R (1993b)
 
Drug:  Sulfadimethoxine
 
Fish species:  Trout, rainbow
 
Date:  1993
 
t1/2-hr:  134
 
Sample:  blood, serum
 
Ave Weight (gm):  240
 
Ave Water temp (°C):  15
 
Water:  Freshwater
 
Dosage:  200 mg/kg sd
 
Route:  PO
 
Comments:  Sampled from caudal vein. Residue ug/g max 3d, 14.5, 0.5h=nd, 1h=nd, 3h=0.89, 6h=1.11, 9h=3.45, 12=2.27, 24h=12.9, 2d=7.14, 3d=14.5, 5d=1.4, 7d=0.28, 10d=0.22, 13d=0.12, 16d=1.68, 20d=nd, 24d=0.90 ug/g. Nd after 28d.
 
Metabolites:  N4-A-SDM
 
Citation:  Aquaculture 115:209-219
 
Dep-time:  36 days
 
Link:  http://dx.doi.org/10.1016/0044-8486(93)90137-N  Opens a new window
 
Genus Species:  Oncorhynchus mykiss
 
Drug Class:  Antibiotic-Sulfa
 
t1/2-detail:  134 h
 
Wt gm-detail:  210-270 g
 
Water temp (°C)-detail:  15 C
 
Dosage-detail:  200 mg/kg sd
 
Method:  HPLC
 
Authors-red:  Uno K, Aoki T, Ueno R (1993b)
 
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