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U.S. Department of Health and Human Services

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Title:  Pharmacokinetics of sulphamonomethoxine and sulphadimethoxine following oral administration to cultured rainbow trout (Oncorhynchus mykiss).
 
Authors:  Uno K, Aoki T, Ueno R (1993b)
 
Drug:  Sulfamonomethoxine
 
Fish species:  Trout, rainbow
 
Date:  1993
 
t1/2-hr:  104
 
Sample:  kidney
 
Ave Weight (gm):  240
 
Ave Water temp (°C):  15
 
Water:  Freshwater
 
Dosage:  300 mg/kg sd
 
Route:  PO
 
Comments:  Residue ug/g max 5d=44.8, 0.5h=0.32, 1h=0.35, 3h=3.16, 6h=8.0, 9h=25.1, 12h=7.48, 24h=35.3, 2d=33.4, 3d=37.1, 5d=44.8, 7d=3.73, 10d=4.79, 13d=0.26, 16d=0.60, 20d=0.41, 24d=0.45, 28d=0.14, 32d=0.26.
 
Metabolites:  N4-A-sulfamonomethoxine
 
Citation:  Aquaculture 115:209-219
 
Dep-time:  40 days
 
Link:  http://dx.doi.org/10.1016/0044-8486(93)90137-N  Opens a new window
 
Genus Species:  Oncorhynchus mykiss
 
Drug Class:  Antibiotic-Sulfa
 
t1/2-detail:  104 h
 
Wt gm-detail:  210-270 g
 
Water temp (°C)-detail:  15 C
 
Dosage-detail:  300 mg/kg sd
 
Method:  HPLC
 
Authors-red:  Uno K, Aoki T, Ueno R (1993b)
 
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