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U.S. Department of Health and Human Services

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Title:  Pharmacokinetics of sulphamonomethoxine and sulphadimethoxine following oral administration to cultured rainbow trout (Oncorhynchus mykiss).
 
Authors:  Uno K, Aoki T, Ueno R (1993b)
 
Drug:  Sulfamonomethoxine
 
Fish species:  Trout, rainbow
 
Date:  1993
 
t1/2-hr:  129
 
Sample:  blood, serum
 
Ave Weight (gm):  240
 
Ave Water temp (°C):  15
 
Water:  Freshwater
 
Dosage:  300 mg/kg sd
 
Route:  PO
 
Comments:  Sampled from caudal vein. Residue ug/g max 3d=14.7, 0.5h=nd, 1h=0.07, 3h=1.53, 6h=5.78, 9h=4.16, 12h=4.71, 24h=15.3, 2d=12.2, 3d=14.7, 5d=9.48, 7d=11.5, 10d= 3.59, 13d=nd, 16d=0.18, 20d=0.20, 24d=0, 28d=0.93, 32d=0.63.
 
Metabolites:  N4-A-sulfamonomethoxine
 
Citation:  Aquaculture 115:209-219
 
Dep-time:  44 days
 
Link:  http://dx.doi.org/10.1016/0044-8486(93)90137-N  Opens a new window
 
Genus Species:  Oncorhynchus mykiss
 
Drug Class:  Antibiotic-Sulfa
 
t1/2-detail:  129 h
 
Wt gm-detail:  210-270 g
 
Water temp (°C)-detail:  15 C
 
Dosage-detail:  300 mg/kg sd
 
Method:  HPLC
 
Authors-red:  Uno K, Aoki T, Ueno R (1993b)
 
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