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U.S. Department of Health and Human Services

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Title:  Single dose pharmacokinetic study of flumequine after intravenous, intraperitoneal and oral administration to Atlantic halibut (Hippoglossus hippoglossus) held in seawater at 9oC.
 
Authors:  Samuelsen OB, Ervik A (1997)
 
Drug:  Flumequine
 
Fish species:  Halibut, Atlantic
 
Date:  1997
 
t1/2-hr:  43
 
Sample:  blood, plasma
 
Ave Weight (gm):  2000
 
Ave Water temp (°C):  9
 
Water:  Saltwater
 
Dosage:  12 mg/kg sd
 
Route:  IV
 
Comments:  t 1/2 '²= 7 +/- 2 h, ³ = 43 +/- 8 h. Residue peak at 3 h= 7.92, 12 h = 3.92, 24 h = 2.28, 96 h= 0.38, 240 = 0.15 ug/ml.
 
Cl:  0.052 L/kg/h
 
Vd:  2.3 L/kg
 
Metabolites:  7-hydroxy-flumequine
 
Citation:  Aquaculture 158:215-227
 
Link:  http://dx.doi.org/10.1016/S0044-8486(97)00190-7  Opens a new window
 
Genus Species:  Hippoglossus hippoglossus
 
Drug Class:  Antibiotic-Quinolone
 
t1/2-detail:  ²= 7 +/- 2 h³ = 43 +/- 8 h
 
Wt gm-detail:  1.5- 2.5 kg
 
Water temp (°C)-detail:  9 C
 
Dosage-detail:  12 mg/kg sd
 
Method:  HPLC
 
Authors-red:  Samuelsen OB, Ervik A (1997)
 
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