Quick Links: Skip to main page content Skip to Search Skip to Topics Menu Skip to Common Links
  • Decrease font size
  • Return font size to normal
  • Increase font size
U.S. Department of Health and Human Services

PhishPharm - Detail
  • Print
  • Share
  • E-mail
-
 
Title:  Comparative pharmacokinetics and bioavailability of oxytetracycline in rainbow trout and Chinook salmon.
 
Authors:  Abedini S, Namdari R, Law FCP
 
Drug:  Oxytetracycline
 
Fish species:  Salmon, chinook
 
Date:  1998
 
t1/2-hr:  88
 
Sample:  blood
 
Ave Weight (gm):  350
 
Ave Water temp (°C):  11
 
Water:  Saltwater
 
Dosage:  50 mg/kg sd
 
Route:  IVC
 
Comments:  Lower Vd than expected in both spp, maybe because implanted cannula; bioavailability of OTC after PO are 24.84% (salmon) and 30.30% (trout) which are higher than normal; Vd= 0.89 l/kg - Chinook in seawater. OTC conc in blood went from 1000 ug/ml to approx 8 ug/ml in first 200 h, down to 1 by 900 h. AUC= 7126.8 ug h/ml
 
Vd:  0.89 L/kg
 
Citation:  Aquaculture 162:23-32
 
Link:  http://dx.doi.org/10.1016/S0044-8486(97)00306-2  Opens a new window
 
Genus Species:  Oncorhynchus tshawytscha
 
Drug Class:  Antibiotic-Tetracycline
 
t1/2-detail:  88.29 h
 
Wt gm-detail:  350 g
 
Water temp (°C)-detail:  11 C
 
Dosage-detail:  50 mg/kg sd
 
Method:  HPLC
 
Authors-red:  Abedini S, Namdari R, Law FCP
 
-
-