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U.S. Department of Health and Human Services

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Title:  Comparative pharmacokinetics and bioavailability of oxytetracycline in rainbow trout and Chinook salmon.
 
Authors:  Abedini S, Namdari R, Law FCP
 
Drug:  Oxytetracycline
 
Fish species:  Trout, rainbow
 
Date:  1998
 
t1/2-hr:  94
 
Sample:  blood
 
Ave Weight (gm):  350
 
Ave Water temp (°C):  11
 
Water:  Freshwater
 
Dosage:  50 mg/kg sd
 
Route:  IVC
 
Comments:  Lower Vd than expected in both spp, maybe because implanted cannula; bioavailability of OTC after PO are 24.84% (salmon) and 30.30% (trout) which are higher than normal; Vd= 0.87l/kg. Conc went from 1000 ug/ml to approx 6 in first 200 h, then to 1 by 900h. AUC = 7781.2 ug h/ml.
 
Vd:  0.87 L/kg
 
Citation:  Aquaculture 162:23-32
 
Link:  http://dx.doi.org/10.1016/S0044-8486(97)00306-2  Opens a new window
 
Genus Species:  Oncorhynchus mykiss
 
Drug Class:  Antibiotic-Tetracycline
 
t1/2-detail:  94.22 h
 
Wt gm-detail:  350 g
 
Water temp (°C)-detail:  11 C
 
Dosage-detail:  50 mg/kg sd
 
Method:  HPLC
 
Authors-red:  Abedini S, Namdari R, Law FCP
 
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