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U.S. Department of Health and Human Services

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Title:  Pharmacokinetics of oxytetracycline in Arctic charr (Salvelinus alpinus L.) in freshwater at low temperature.
 
Authors:  Haug T, Hals PA
 
Drug:  Oxytetracycline
 
Fish species:  Char, Arctic
 
Date:  2000
 
t1/2-hr:  266
 
Sample:  blood, plasma
 
Ave Weight (gm):  454
 
Ave Water temp (°C):  6
 
Water:  Freshwater
 
Dosage:  10 mg/kg sd
 
Route:  IVC
 
Comments:  t1/2 alpha=1.5 hr, beta 16.5, gamma=266.3. AUC 1591.4 ug h/ml. Cannulated fish.
 
Cl:  0.007 L/kg/h
 
Vc:  0.13+/-49.2 L/kg
 
Vd:  1.98 +/- 0.60 L/kg
 
Citation:  Aquaculture 186:175-191
 
Link:  http://dx.doi.org/10.1016/S0044-8486(99)00376-2  Opens a new window
 
Genus Species:  Salvelinus alpinus alpinus
 
Drug Class:  Antibiotic-Tetracycline
 
t1/2-detail:  t1/2 alpha=1.5 hr, beta 16.5, gamma=266.3
 
Wt gm-detail:  454+/-149 g
 
Water temp (°C)-detail:  4.2-8.6 C
 
Dosage-detail:  10 mg/kg sd
 
Method:  HPLC
 
Authors-red:  Haug T, Hals PA
 
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