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U.S. Department of Health and Human Services

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Title:  Poor bioavailability of oxytetracycline in sharpsnout sea bream Diplodus puntazzo.
 
Authors:  Rigos G, Tyrpenou AE, Nengas I, Alexis AEM, Athanassopoulou, Troisi GM
 
Drug:  Oxytetracycline
 
Fish species:  Seabream, sharpsnout
 
Date:  2004
 
t1/2-hr:  35
 
Sample:  blood, plasma
 
Ave Weight (gm):  90
 
Ave Water temp (°C):  19
 
Water:  Saltwater
 
Dosage:  40 mg/kg sd
 
Route:  IV
 
Comments:  Salt water 36 ppt. AUC = 549 ug/h ml. Residues ug/ml 1h=18.6, 2h=14.1, 4h=12.4, 8h=9.9, 16h=7.7, 24h=5.8, 48h=4.0, 72h=1.6, 150h=0.9.
 
Cl:  0/08L/kg/h
 
Vc:  1.7+/-0.03 L/kg
 
Vd:  4 L/kg
 
Citation:  Aquaculture 235:489-497
 
Link:  http://dx.doi.org/10.1016/j.aquaculture.2003.10.016  Opens a new window
 
Genus Species:  Diplodus puntazzo
 
Drug Class:  Antibiotic-Tetracycline
 
t1/2-detail:  1.4 alpha, 34.5+/-3 h beta
 
Wt gm-detail:  90+/-20 g
 
Water temp (°C)-detail:  19+/-0.5 C
 
Dosage-detail:  40 mg/kg sd
 
Method:  HPLC
 
Authors-red:  Rigos G, Tyrpenou AE, Nengas I, Alexis AEM, Athanassopoulou, Troisi GM
 
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