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Title:  A question of temperature related differences in plasma oxolinic acid concentrations achieved in rainbow trout (Oncorhynchus mykiss) under laboratory conditions following multiple oral dosing.
 
Authors:  Coyne R, Bergh O, Smith P, Samuelsen O.
 
Drug:  Oxolinic acid
 
Fish species:  Trout, rainbow
 
Date:  2004
 
Sample:  blood, plasma
 
Ave Weight (gm):  188
 
Ave Water temp (°C):  6
 
Water:  Saltwater
 
Dosage:  50mg/kg 6 d*
 
Route:  PO
 
Comments:  Lab fish: Medicated feed 5g/kg fed at 1% body wt on days 1,2,3,5,7,9. Not all fish ate, 24 hr post last feeding residues were detecdted in 42 of 49 fish. Mean residue, mg/l, 24 after last feeding =0.15. Compared with previous study at 12C, mean ug/l at 24h post feed =0.14. 80th percentile 6C=0.08, 12C=0.09. Coef. of variation 6C=66%, 12C=47%.
 
Citation:  Aquaculture 245:13-17
 
Link:  http://dx.doi.org/10.1016/j.aquaculture.2004.11.039  Opens a new window
 
Genus Species:  Oncorhynchus mykiss
 
Drug Class:  Antibiotic-Quinolone
 
Wt gm-detail:  188+/-47g
 
Water temp (°C)-detail:  6C
 
Dosage-detail:  Medicated feed 50mg/kg for 6 d*
 
Method:  HPLC
 
Authors-red:  Coyne R, Bergh O, Smith P, Samuelsen O.
 
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