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Title:
The biopharmaceutics and oral bioavailability of two forms of oxytetracycline to the white shrimp, Litopenaeus setiferus.
Authors:
Reed LA, Siewicki TC, Shah JC
Drug:
Oxytetracycline
Fish species:
Shrimp, northern white
Date:
2006
t1/2-hr:
10
est:
est
Sample:
blood, hemolymph
Ave Weight (gm):
23
Ave Water temp (°C):
21
Water:
Saltwater
Dosage:
100 mg/kg 1 d
Route:
PO
Comments:
Tested OTC dihydrate formulation. 2x more soluble than quaternary salt form. Salinity=20ppt. Tmax=25.4+/-3.1 h. Cmax=35.4+/-14.7 ug/mL. AUC=1410+/-546 ug h/mL. F=92.2+/-32.7%. Vd=Vc+Vp. Dep-time est 4 d from curve. t1/2-alpha and beta extrapolated from curve. Bioavail=92%
Vc:
715 mL/kg
Vd:
2310 mL/kg
Citation:
Aquaculture 258:42-54
Dep-time:
4 d
Link:
http://dx.doi.org/10.1016/j.aquaculture.2006.03.029
Genus Species:
Litopenaeus setiferus
Drug Class:
Antibiotic-Tetracycline
t1/2-detail:
alpha= 5 h est beta=10 h est
Wt gm-detail:
14.92-31.44g
Water temp (°C)-detail:
20+/-2 C
Dosage-detail:
100 mg/kg 1 d
Method:
HPLC
Authors-red:
Reed LA, Siewicki TC, Shah JC
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