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U.S. Department of Health and Human Services

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Title:  Bioavailability and absorption analysis of oxytetracycline orally administered to the standardized moulting farmed farmed Pacific white shrimps (Panaeus vannamei).
 
Authors:  Faroongsarng D, Chandumpai A, Chiayvareesajja S, Theapparat Y
 
Drug:  Oxytetracycline
 
Fish species:  Shrimp, whiteleg
 
Date:  2007
 
t1/2-hr:  92
 
Sample:  blood, hemolymph
 
Ave Weight (gm):  18
 
Ave Water temp (°C):  28
 
Water:  Saltwater
 
Dosage:  51.4 mg/kg sd8
 
Route:  PO
 
Comments:  Cmax = 43.52 ug/mlL at 7 hr. AUC term = 1110 ug h/mL, AUCinf = 1155 ug h/mL, Transit = 71.5, Bioavailability = 80.6 %. Reported values: Cl = 0.035 mL/hr, Vd = 4.63 mL/g. Salinity 20 ppt. *abstract states incorrect dose (50 ug/gm vs 50 ug/Kg). Compare with Chiayvareesajja et 2006.
 
Cl:  0.035 mL/hr
 
Vd:  4.63 L/kg
 
Citation:  Aquaculture 269:89-97
 
Link:  http://dx.doi.org/10.1016/j.aquaculture.2007.04.019  Opens a new window
 
Genus Species:  Litopenaeus vannamei
 
Drug Class:  Antibiotic-Tetracycline
 
t1/2-detail:  91.9 +/- 51.5 h
 
Wt gm-detail:  14-22 g
 
Water temp (°C)-detail:  28 +/- 2 C
 
Dosage-detail:  51.4 ug/g
 
Method:  HPLC
 
Authors-red:  Faroongsarng D, Chandumpai A, Chiayvareesajja S, Theapparat Y
 
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