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U.S. Department of Health and Human Services

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Title:  Plasma and tissue depletion of florfenicol in olive flounder (Paralichthys olivaceus) after oral administration.
 
Authors:  Lim JH, Kim MS, Hwang YH, Song IB, Park BK, Yun HI
 
Drug:  Florfenicol
 
Fish species:  Halibut, bastard
 
Date:  2010
 
Sample:  liver
 
Ave Weight (gm):  380
 
Ave Water temp (°C):  19
 
Water:  Saltwater
 
Dosage:  20 mg/kg 3d
 
Route:  PO
 
Comments:  Salinity at 33 ppt. Florfenicol amine was not detected in tissue. Tissue concentrations of florfenicol were slowly depleted from the liver, muscle and gill tissues and below maximum residue limit at 7d after last dose. Tissue concentration of florfenicol: 1d post-dose= 2.35 mg/kg, 3d post-dose= 1.25 mg/kg, 7d post-dose= 0.29 mg/kg. Tissue/plasma ratio: 1d post-dose= 0.73, 3d post-dose= 0.55, 7d post-dose= 0.44.
 
Metabolites:  Florfenicol amine
 
Citation:  Aquaculture 307: 71-74
 
Link:  dx.doi.org/10.1016/j.aquaculture.2010.07.003   Opens a new window
 
Genus Species:  Paralichthys olivaceus
 
Drug Class:  Antiobiotic-phenicol
 
Wt gm-detail:  380.4+/- 20.8g
 
Water temp (°C)-detail:  18.5+/- 1.7C
 
Dosage-detail:  20 mg/kg/d 3d
 
Method:  LC/MS
 
Authors-red:  Lim JH, Kim MS, Hwang YH, Song IB, Park BK, Yun HI
 
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