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Title:  Study on the pharmacokinetics of enrofloxacin in the Chinese mitten-handed crab, Eriocheir sinensis, after different administration regimes
 
Authors:  Jingbo Z, Guanghong W, Yong M, Xinglian X
 
Drug:  Enrofloxacin
 
Fish species:  Crab, Chinese mitten-handed
 
Date:  2008
 
t1/2-hr:  240
 
Sample:  hepatopancreas
 
Ave Weight (gm):  91
 
Ave Water temp (°C):  17
 
Water:  Freshwater
 
Dosage:  3 mg/kg
 
Route:  IM
 
Comments:  T1/2 alpha=1.8. AUC=2149. Intramuscular administrated enrofloxacin (ENR) in muscle absorbed and eliminated faster than bath treatment and oral administration. ENR levels in hepatopancreas and muscle following IM injection were higher than those following PO administration. The metabolite ciprofloxacin (CIP) was much higher in hepatopancreas than muscle. CIP rose through the last sampling time (168h) which was at a level of 2.35 ug/g.
 
Cl:  0.0014 L/kg/h
 
Vc:  0.77 L/kg
 
Metabolites:  Ciprofloxacin
 
Citation:  Aquaculture Research 39: 1210-1215
 
Link:  http://dx.doi.org/10.1111/j.1365-2109.2008.01985.x  Opens a new window
 
Genus Species:  Eriocheir sinensis
 
Drug Class:  Antibiotic-Quinolone
 
t1/2-detail:  240.27
 
Wt gm-detail:  80.3-102.3
 
Water temp (°C)-detail:  17+/-1
 
Dosage-detail:  0.1 mL ENR = 3mg/mL
 
Method:  HPLC
 
Authors-red:  Jingbo Z, Guanghong W, Yong M, Xinglian X
 
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