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Title:  Pharmacokinetics and tissue residues of marbofloxacin in crucian carp (Carassius auratus) after oral administration
 
Authors:  Zhu Y, Tan Y, Wang C, Zhang N, Liu Y, Liu L, Li C, Lu X, Cao J
 
Drug:  Marbofloxacin
 
Fish species:  Carp, crucian (goldfish)
 
Date:  2009
 
t1/2-hr:  51
 
Sample:  blood, plasma
 
Ave Weight (gm):  250
 
Ave Water temp (°C):  15
 
Water:  Freshwater
 
Dosage:  10 mg/kg sd
 
Route:  PO
 
Comments:  Mean concentrations: 0.17h=1.0, 0.5h=3.7, 0.75h=6.8, 0.92h=5.6, 1h=5.1, 2h=7.4, 3h=6.2, 4h=5.7, 6h=4.5, 9h=4.2, 12h=4.3, 16h=4.0, 24h=2.6, 48h=2.0, 72h=1.4. Cmax=6.43 mg mL at 1.74h. T1/2 alpha=4.48
 
Cl:  0.03 L h kg
 
Vd:  1.36 L kg
 
Citation:  Aquaculture Research 40: 696-709
 
Link:  http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2109.2008.02146.x/abstract  Opens a new window
 
Genus Species:  Carassius auratus auratus
 
Drug Class:  Antibiotic-Quinolone
 
t1/2-detail:  50.75
 
Wt gm-detail:  250 +/- 30 g
 
Water temp (°C)-detail:  15 +/- 1 C
 
Dosage-detail:  10 mg/kg sd
 
Method:  HPLC
 
Authors-red:  Zhu Y, Tan Y, Wang C, Zhang N, Liu Y, Liu L, Li C, Lu X, Cao J
 
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