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Title:
Dose-response relationships and pharmacokinetics of vitellogenin in rainbow trout after intravascular administration of 17[alpha]-ethynylestradiol.
Authors:
Schultz IR, Orner G, Merdink JL, Skillman A
Drug:
Vitellogenin
Fish species:
Trout, rainbow
Date:
2001
t1/2-hr:
43
Sample:
blood, plasma
Ave Weight (gm):
1410
Ave Water temp (°C):
12
Water:
Freshwater
Dosage:
10 mg/kg sd
Route:
IVC
Comments:
Cannulated fish. Vitellogenin administered directly (compare with 17alpha-ethynylestradiol administration). AUC ug/ml/h=296
Cl:
0.0311 L/kg/h
Vd:
0.837L/kg
Citation:
Aquatic Toxicology 51:305-318
Link:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11090892&query_hl=4
Genus Species:
Oncorhynchus mykiss
Drug Class:
Hormone-Estrogen
t1/2-detail:
43.7 h
Wt gm-detail:
1410+/-307 g
Water temp (°C)-detail:
12 C
Dosage-detail:
10 mg/kg sd
Method:
ELISA
Authors-red:
Schultz IR, Orner G, Merdink JL, Skillman A
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