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Title:
Toxic effects of the non-steroidal anti-inflammmatory drug diclofenac Part I: histopathological alterations and bioaccumulation in rainbow trout.
Authors:
Schwaiger J, Ferling H, Mallow U, Wintermayr H, Negele RD
Drug:
Diclofenac
Fish species:
Trout, rainbow
Date:
2004
Sample:
muscle
Ave Weight (gm):
167
Ave Water temp (°C):
10
Water:
Not Specified
Dosage:
0.001mg/L 28d
Route:
BATH
Comments:
Fish were anesthetized in ethylenglycol monophenylether, then decapitated. Diclofenac concentration after 28d at 1ug/L dose=72.8 ng/g. Bioconcentration factor (BCF) decreased as dose increased. BCF=69.
Citation:
Aquatic Toxicology 68:141-150
Link:
http://dx.doi.org/10.1016/j.aquatox.2004.03.014
Genus Species:
Oncorhynchus mykiss
Drug Class:
Anti-inflammatory-Non-steroidal
Wt gm-detail:
167.6+/-20.28g
Water temp (°C)-detail:
10.3C
Dosage-detail:
Target=1ug/L, actual=1.06+/-0.05
Method:
GC/MS
Authors-red:
Schwaiger J, Ferling H, Mallow U, Wintermayr H, Negele RD
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