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U.S. Department of Health and Human Services

PhishPharm - Detail
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Title:  Uptake, tissue distribution and excretion of domoic acid after oral exposure in coho salmon (Oncorhynchus kisutch).
 
Authors:  Lefebvre KA, Noren DP, Schultz IR, Bogard SM, Wilson J, Eberhart BTL
 
Drug:  Domoic acid
 
Fish species:  Salmon, coho
 
Date:  2007
 
Sample:  brain
 
Ave Weight (gm):  38
 
Ave Water temp (°C):  11
 
Water:  Freshwater
 
Dosage:  6.3 mg/kg sd
 
Route:  IC
 
Comments:  The onset of neuroexcitotoxic behavior following IC (intraccoelomic)injection was 30 +/-8 min. The mean level of domoic acid in brain resulting in this behavior was 170 +/- 28 ng/g tissue.
 
Citation:  Aquatic Toxicology 81:266-274
 
Link:  http://dx.doi.org/10.1016/j.aquatox.2006.12.009  Opens a new window
 
Genus Species:  Oncorhynchus kisutch
 
Drug Class:  Organic-Phycotoxin
 
Wt gm-detail:  38 +/- 2g
 
Water temp (°C)-detail:  11 C
 
Dosage-detail:  6.3 mg/kg of demoic acid was administered via intracoelomic injection once
 
Method:  ELISA
 
Authors-red:  Lefebvre KA, Noren DP, Schultz IR, Bogard SM, Wilson J, Eberhart BTL
 
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