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U.S. Department of Health and Human Services

PhishPharm - Detail
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Title:  Behavioral and biochemical responses of hybrid striped bass during and after fluoxetine exposure
 
Authors:  Gaworecki KM, Klaine SJ
 
Drug:  Fluoxetine
 
Fish species:  Bass, striped (hybrid)
 
Date:  2008
 
Sample:  brain
 
Ave Weight (gm):  163
 
Ave Water temp (°C):  25
 
Water:  Freshwater
 
Dosage:  150 ug/l 6 d
 
Route:  BATH
 
Comments:  Euthanized in buffered MS-222. Brain serotonin levels in low, medium, and high fluoxitine treatments decreased as exposure time increased with maximum depression occurring on day 9 (3 days post exposure). Seratonin levels were depressed 49.1% by day 9. 5-HIAA levels were significantly depressed as a result of fluoxetine exposure in all treatment groups.
 
Metabolites:  5-Hydroxyindoleacetic acid (5-HIAA)
 
Citation:  Aquatic Toxicology 88: 207-213
 
Link:  http://dx.doi.org/10.1016/j.aquatox.2008.04.011  Opens a new window
 
Genus Species:  Morone saxatilis x M. chrysops (hybrid)
 
Drug Class:  Anti-Depressant-Serotonin
 
Wt gm-detail:  163.4+/-27.4
 
Water temp (°C)-detail:  23.8+/-1.07
 
Dosage-detail:  100.9+/-18.6 ug/l
 
Method:  HPLC
 
Authors-red:  Gaworecki KM, Klaine SJ
 
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