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U.S. Department of Health and Human Services

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Title:  Kinetics and effects of dichloroacetic acid in rainbow trout
 
Authors:  Fitzsimmons PN, Hoffman AD, Lien GJ, Hammermeister DE, Nichols JW
 
Drug:  Dichloroacetic acid
 
Fish species:  Trout, rainbow
 
Date:  2009
 
Sample:  bile
 
Ave Weight (gm):  900
 
Ave Water temp (°C):  11
 
Water:  Freshwater
 
Dosage:  200 mg/L 72 hrs
 
Route:  BATH
 
Comments:  Inhalation experiment. Each fish was spinally transected, fitted with a uninary catheter and cannulated from the dorsal aorta. A latex membrane was sewn around the fish's mouth to separate inspired and expired water. A second membrane just posterior to the pectoral fins prevented dilution of expired water. Fish were allowed to recover 24-48 hrs before the start of the experiment. DCA concentration (mean n=4) = 0.03
 
Citation:  Aquatic Toxicology 94: 186-194
 
Link:  http://dx.doi.org/10.1016/j.aquatox.2009.07.001  Opens a new window
 
Genus Species:  Oncorhynchus mykiss
 
Drug Class:  Halogenated acetic acids
 
Wt gm-detail:  800-1000
 
Water temp (°C)-detail:  11+/-1
 
Dosage-detail:  Target dose=200mg/L, actual=173.1 mg/L
 
Method:  HPLC-UV, GC/ECD
 
Authors-red:  Fitzsimmons PN, Hoffman AD, Lien GJ, Hammermeister DE, Nichols JW
 
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