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U.S. Department of Health and Human Services

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Title:  Chronic effects assessment and plasma concentrations of the Beta-blocker propranolol in fathead minnows (Pimephales promelas)
 
Authors:  Giltrow E, Eccles PD, Winter MJ, McCormack PJ, Rand-Weaver M, Hutchinson TH, Sumpter JP
 
Drug:  Propanolol
 
Fish species:  Minnow, fathead
 
Date:  2009
 
Sample:  blood, plasma
 
Ave Weight (gm):  3
 
Ave Water temp (°C):  25
 
Water:  Freshwater
 
Dosage:  1 mg/L 11 d
 
Route:  BATH
 
Comments:  Fish were euthaized with MS-222 (0.5mg/L). All fish at 1 mg/L showed reduced feeding rates. By day 4 two males were euthanized due to distress. Their female pairs were euthanized on day 5 due to distress. One fish found outside of its tank on day 11, at which point all fish at this dose were euthanized, therefore all data is for 11 days (vs 21d for all others). Cumulative egg production: 0. Gonadal somatic index (%): Male-0.8, Female-13. Condition index: Male-1.3, Female 1.2. A high proportion of eggs (75-95%) from exposed fish pairs hatched. Egg hatch delayed by 3 days. Mean plasma concentration (mg/L): Male-15.00, Female-5.75.
 
Citation:  Aquatic Toxicology 95: 195-202
 
Link:  http://dx.doi.org/10.1016/j.aquatox.2009.09.002  Opens a new window
 
Genus Species:  Pimephales promelas
 
Drug Class:  Beta adrenoreceptor blocker: non-specific
 
Wt gm-detail:  Males ranged 2.433-5.680g, females ranged 0.811-2.490g
 
Water temp (°C)-detail:  25+/-1
 
Dosage-detail:  Mean = 0.97 mg/L
 
Method:  LC/SPE
 
Authors-red:  Giltrow E, Eccles PD, Winter MJ, McCormack PJ, Rand-Weaver M, Hutchinson TH, Sumpter JP
 
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