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U.S. Department of Health and Human Services

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Title:  Comparative toxicokinetics of explosive compounds in Sheepshead minnows.
 
Authors:  Lotufo GR, Lydy MJ
 
Drug:  Toluene-(TNT-Trinitrotoluene-metabolite 2-ADNT)
 
Fish species:  Minnow, sheepshead
 
Date:  2005
 
t1/2-hr:  1
 
Sample:  whole body
 
Ave Water temp (°C):  23
 
Water:  Saltwater
 
Dosage:  3.0 mg/L up to 6 h
 
Route:  BATH
 
Comments:  Ku-uptake (ml/g/h) = 12.6, Ke=0.957/h, BCF=13.2 mg/g. No trend between elimination rate ahdn hydrophobicity among the chemicals studied (RDX and HMX slower than TNT and its metabolites.
 
Metabolites:  2-aminodinitrotoluene (2-ADNT)
 
Citation:  Archives of Environmental Contamination and Toxiciology
 
Link:  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16059748&query_hl=3  Opens a new window
 
Genus Species:  Cyprinodon variegatus variegatus
 
Drug Class:  Organic-Hydrocarbon
 
t1/2-detail:  0.72 h
 
Wt gm-detail:  12 wk juvenile
 
Water temp (°C)-detail:  23 C
 
Dosage-detail:  3.0 mg/L up to 6 h
 
Method:  HPLC
 
Authors-red:  Lotufo GR, Lydy MJ
 
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