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Title:
The pharmacology of MS 222 (Ethyl-m-aminobenzoate) in Squalus acanthias.
Authors:
Stenger VG, Maren TH
Drug:
MS-222
Fish species:
Shark, picked dogfish
Date:
1974
t1/2-hr:
1
Sample:
blood, plasma
Ave Weight (gm):
1650
Ave Water temp (°C):
0
Water:
Saltwater
Dosage:
30 mg/kg
Route:
IVC
Comments:
Gill clearance ranged between 7.9-13.9 ml per kg/min. Renal excrtion acounts for about 5 percent of toal drug injected. Residues in plasma for 2 fish = at 0 h withdrawal = 7.2 or 6.5, Depletion evaluated at 5 min = 6.4 or 6.1 (2 fish), and in one fish at 10 and 15 min (5.8, 5.2 ug/ml).
Metabolites:
m-aminobenzoic acid, m-acetylaminobnzoic acid, N-acetyl derivative
Citation:
Comparative and General Pharmacology 5:23-35
Link:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=4156511
Genus Species:
Squalus acanthias
Drug Class:
Anesthetic-Tricaine
t1/2-detail:
56 min
Wt gm-detail:
1.4-1.9 kg
Water temp (°C)-detail:
Not specified
Dosage-detail:
30 mg/kg
Method:
Absorbance-Bratton&Marshall, TLC
Authors-red:
Stenger VG, Maren TH
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