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U.S. Department of Health and Human Services

PhishPharm - Detail
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Title:  The pharmacology of MS 222 (Ethyl-m-aminobenzoate) in Squalus acanthias.
 
Authors:  Stenger VG, Maren TH
 
Drug:  MS-222
 
Fish species:  Shark, picked dogfish
 
Date:  1974
 
t1/2-hr:  1
 
Sample:  blood, plasma
 
Ave Weight (gm):  1650
 
Ave Water temp (°C):  0
 
Water:  Saltwater
 
Dosage:  35 mg/kg
 
Route:  IVC
 
Comments:  Gill clearance ranged between 7.9-13.9 ml per kg/min. Renal excrtion acounts for about 5 percent of toal drug injected. Residues in plasma = at 0 h withdrawal = 22.6, one fish and 7.1 another fish. The second fish had depletion evaluated at 5, 10 and 15 min (5.6, 4.9, 4.2 ug/ml).
 
Metabolites:  m-aminobenzoic acid, m-acetylaminobnzoic acid, N-acetyl derivative
 
Citation:  Comparative and General Pharmacology 5:23-35
 
Link:  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=4156511  Opens a new window
 
Genus Species:  Squalus acanthias
 
Drug Class:  Anesthetic-Tricaine
 
t1/2-detail:  56 min
 
Wt gm-detail:  1.4-1.9 kg
 
Water temp (°C)-detail:  Not specified
 
Dosage-detail:  35 mg/kg
 
Method:  Absorbance-Bratton&Marshall, TLC
 
Authors-red:  Stenger VG, Maren TH
 
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