Quick Links: Skip to main page content Skip to Search Skip to Topics Menu Skip to Common Links
  • Decrease font size
  • Return font size to normal
  • Increase font size
U.S. Department of Health and Human Services

PhishPharm - Detail
  • Print
  • Share
  • E-mail
-
 
Title:  Pharmacokinetics of morphine in fish: Winter flounder (Pseudopleuronectes americanus) and seawater-acclimated rainbow trout (Oncorhyncus mykiss).
 
Authors:  Newby NC, Mendonca PC, Gamperl K, Stevens ED
 
Drug:  Morphine
 
Fish species:  Flounder, winter
 
Date:  2006
 
t1/2-hr:  19
 
Sample:  blood, plasma
 
Ave Weight (gm):  433
 
Ave Water temp (°C):  10
 
Water:  Saltwater
 
Dosage:  17.4 mg/kg
 
Route:  IV
 
Comments:  A = 104 +/- 16.1 mg/L, ± = 1.27 +/- 0.09 per hour, B = 6.95 +/- 0.53 mg/L, ² = 0.0274 +/- 0.005 per hour, C0 = 111 +/- 15.7, AUCarea 340 +/- 12 mg h/L, AUMCarea 11,850 +/- 42 mg h2/L, MRTarea = 29.3 +/- 1.0 h. (Morphine Sulfate).
 
Vd:  1.42 +/- 0.137 L
 
Citation:  Comparative Biochemistry and Physiology 143C:275-283
 
Link:  http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=16631414&ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum  Opens a new window
 
Genus Species:  Pseudopleuronectes americanus
 
Drug Class:  Analgesic-Morphine
 
t1/2-detail:  19.1 +/- 1.23
 
Wt gm-detail:  433 +/- 16 g
 
Water temp (°C)-detail:  4 C initally acclimated to 10 C
 
Dosage-detail:  7.5 mg/kg
 
Method:  ELISA
 
Authors-red:  Newby NC, Mendonca PC, Gamperl K, Stevens ED
 
-
-