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U.S. Department of Health and Human Services

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Title:  Pharmacokinetics of morphine in fish: Winter flounder (Pseudopleuronectes americanus) and seawater-acclimated rainbow trout (Oncorhyncus mykiss).
 
Authors:  Newby NC, Mendonca PC, Gamperl K, Stevens ED
 
Drug:  Morphine
 
Fish species:  Flounder, winter
 
Date:  2006
 
t1/2-hr:  34
 
Sample:  blood, plasma
 
Ave Weight (gm):  565
 
Ave Water temp (°C):  10
 
Water:  Saltwater
 
Dosage:  39 mg/kg sd
 
Route:  IP
 
Comments:  A = 63.5 +/- 8.0 mg/L, ± = 0.434 +/- 0.083 per hour, B = 8.76 +/- 2.19 mg/L, ² = 0.0274 +/- 0.0054 per hour, T1/2dist = 2.20 +/- 0.46 h, AUCexpo = 513 +/- 72 mg h/L, AUCarea = 583 +/- 74 mg h/L, AUMCexpo = 18,600 +/- 5970 mg h2/L, AUMCarea = 18,600 +/- 5990 h2/L, MRTarea = 27.9 +/- 6.6 h (Morphine Sulfate).
 
Cl:  0.076 L/kg/h
 
Citation:  Comparative Biochemistry and Physiology 143C:275-283
 
Link:  http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=16631414&ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum  Opens a new window
 
Genus Species:  Pseudopleuronectes americanus
 
Drug Class:  Analgesic-Morphine
 
t1/2-detail:  34.1 +/- 7.3 h
 
Wt gm-detail:  565 +/- 76 g
 
Water temp (°C)-detail:  4 C initally acclimated to 10 C
 
Dosage-detail:  39.0 +/- 0.3 mg/kg
 
Method:  ELISA
 
Authors-red:  Newby NC, Mendonca PC, Gamperl K, Stevens ED
 
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