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U.S. Department of Health and Human Services

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Title:  Quantitative analysis of alterations in liver ultrastructure of rainbow trout Oncorhynchus mykiss after administration of the aquaculture antibacterials oxolinic acid and flumequine.
 
Authors:  Moutou KA, Braunbeck T, Houlihan DF
 
Drug:  Flumequine
 
Fish species:  Trout, rainbow
 
Date:  1997
 
Sample:  liver
 
Ave Weight (gm):  0
 
Ave Water temp (°C):  0
 
Water:  Freshwater
 
Dosage:  1.2 g/kg 10 d
 
Route:  PO
 
Comments:  Ultrastructure of liver showed 2.5 increase in volume of rough endoplasmic reticulum - dilation, vesiculation and fragmentation. Bycogen deposits were depleted by 50%. Intralysosomal accumulation of stacked membranes and myelin figures in cytoplasm. Mitochondiral hyperplasia.
 
Citation:  Diseases of Aquatic Organisms 29:21-34 Abstract
 
Link:  http://www.int-res.com/abstracts/dao/v29/n1/p21-34/  Opens a new window
 
Genus Species:  Oncorhynchus mykiss
 
Drug Class:  Antibiotic-Quinolone
 
Wt gm-detail:  Not specified
 
Water temp (°C)-detail:  Not specified
 
Dosage-detail:  1.2 g/kg 10 d
 
Method:  Rad
 
Authors-red:  Moutou KA, Braunbeck T, Houlihan DF
 
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