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U.S. Department of Health and Human Services

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Title:  Metabolism of praziquantel in kingfish Seriola lalandi
 
Authors:  Tubbs L, Mathieson T, Tingle M.
 
Drug:  Praziquantel
 
Fish species:  Amberjack, yellowtail (kingfish)
 
Date:  2008
 
Sample:  muscle
 
Ave Weight (gm):  3000
 
Ave Water temp (°C):  19
 
Water:  Saltwater
 
Dosage:  150 mg/kg
 
Route:  PO
 
Comments:  Fish were anaesthetized with 2-phenoxyethanol (300 ppm). Praziquantel (PZQ) was detected in all tissues. Seven metabolites were detected (M1-M7), which correspond to mono- and dihydroxylated PZQ, with the highest number detected in the liver. Metabolite M7 was prominent in all tissues with a retention time of 26.3 minutes.
 
Metabolites:  7 mono- or dihydroxylated derivatives
 
Citation:  Diseases of Aquatic Organisms 78: 225-233
 
Link:  http://www.int-res.com/abstracts/dao/v78/n3/p225-233/  Opens a new window
 
Genus Species:  Seriola lalandi
 
Drug Class:  Antiparasitic-Praziquantel
 
Wt gm-detail:  3 kg
 
Water temp (°C)-detail:  18-19
 
Dosage-detail:  150 mg/kg
 
Method:  LC/MS, HPLC-UV
 
Authors-red:  Tubbs L, Mathieson T, Tingle M.
 
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