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U.S. Department of Health and Human Services

PhishPharm - Detail
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Title:  Relative roles of metabolism and renal excretory mechanisms in xenobiotic elimination by fish.
 
Authors:  Pritchard JB, Bend JR
 
Drug:  BAP-(Benzo-a-pyrene)
 
Fish species:  Flounder, southern
 
Date:  1991
 
Sample:  urine
 
Ave Weight (gm):  1750
 
Ave Water temp (°C):  23
 
Water:  Saltwater
 
Dosage:  2.5 umol/kg
 
Route:  IV/IM
 
Comments:  Half the dose administerd IV, the remainder was given IM. BaP (3H). Given with polyethyleneglycol (14C) as marker for GFR. 6.4nmole/ml.
 
Cl:  0.7 ml/h
 
Metabolites:  7-OH-BaP
 
Citation:  Environmental Health Perspectives 90:85-92
 
Link:  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=2050085  Opens a new window
 
Genus Species:  Paralichthys lethostigma
 
Drug Class:  Organic-Hydrocarbon
 
Wt gm-detail:  500-3000 g
 
Water temp (°C)-detail:  22-24 C
 
Dosage-detail:  2.5 umol/kg
 
Method:  HPLC
 
Authors-red:  Pritchard JB, Bend JR
 
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