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U.S. Department of Health and Human Services

PhishPharm - Detail
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Title:  Relative roles of metabolism and renal excretory mechanisms in xenobiotic elimination by fish.
 
Authors:  Pritchard JB, Bend JR
 
Drug:  BAP-(Benzo-a-pyrene)
 
Fish species:  Flounder, southern
 
Date:  1991
 
Sample:  urine
 
Ave Weight (gm):  1750
 
Ave Water temp (°C):  13
 
Water:  Saltwater
 
Dosage:  2.5 umol/kg
 
Route:  IV/IM
 
Comments:  Half the dose administerd IV, the remainder was given IM. BaP (3H). Given with polyethyleneglycol (14C) as marker for GFR. Urine levels reduced in low temperature fish (4.7 uM vs 17.1 in controls at 23C).
 
Metabolites:  BaP7,8 diol
 
Citation:  Environmental Health Perspectives 90:85-92
 
Link:  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=2050085  Opens a new window
 
Genus Species:  Paralichthys lethostigma
 
Drug Class:  Organic-Hydrocarbon
 
Wt gm-detail:  500-3000 g
 
Water temp (°C)-detail:  12-14 C
 
Dosage-detail:  2.5 umol/kg
 
Method:  HPLC
 
Authors-red:  Pritchard JB, Bend JR
 
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