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U.S. Department of Health and Human Services

PhishPharm - Detail
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Title:  Total residue depletion and metabolic profile of selected drugs in salmonids: Acriflavine and Proflavine.
 
Authors:  Hayton WL (1997e)
 
Drug:  Proflavine
 
Fish species:  Trout, rainbow
 
Date:  1997
 
t1/2-hr:  26
 
Sample:  blood, plasma
 
Ave Weight (gm):  601
 
Ave Water temp (°C):  12
 
Water:  Freshwater
 
Dosage:  4 mg/l 4 hr
 
Route:  BATH
 
Comments:  Metabolites only identified in kidney, liver and bile. Concentration of radioactivity (ppb) at 4h exposure = 52.3, withdrawal day 2 = 11.0, day 4= 10.7, withdrawal day 8 = 4.31. Proflavine (14C).
 
Protein binding:  0.809
 
Cl:  1.05 L/kg/h
 
Vd:  28.2 L/kg
 
Metabolites:  3-N-glucuronosyl proflavine, 3-N-glucuronosyl, 6-N-acetyl proflavine, 3-N-acetyl proflavine
 
Citation:  Final FDA Report. Contract 223-93-7014. Vol 1. Study 728363-004.
 
Link:  none  Opens a new window
 
Genus Species:  Oncorhynchus mykiss
 
Drug Class:  Organic-Dye
 
t1/2-detail:  26 h
 
Wt gm-detail:  601 +/- 122 g
 
Water temp (°C)-detail:  12 C
 
Dosage-detail:  4 ppm 4 hr
 
Method:  HPLC-Rad
 
Authors-red:  Hayton WL (1997b)
 
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