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Title:
Total residue depletion and metabolic profile of selected drugs in salmonids: Acriflavine and Proflavine.
Authors:
Hayton WL (1997d)
Drug:
Acriflavine
Fish species:
Trout, rainbow
Date:
1997
t1/2-hr:
38
Sample:
blood, plasma
Ave Weight (gm):
443
Ave Water temp (°C):
12
Water:
Freshwater
Dosage:
4 mg/l 4 hr
Route:
BATH
Comments:
Acriflavine (14C) After 4 hour exposure total residue in plasma = 204 ppb, after 8 days levels were 3.32%, after 16 d= 2% (or less) of 0 depuration values.
Cl:
1.08 L/kg/h
Vd:
31.2 L/kg
Metabolites:
Unidentified metabolites
Citation:
Final FDA Report. Contract 223-93-7014. Vol 1. Study 728363-008.
Link:
none
Genus Species:
Oncorhynchus mykiss
Drug Class:
Organic-Dye
t1/2-detail:
38 h
Wt gm-detail:
443 +/- 35.5 g
Water temp (°C)-detail:
12 C
Dosage-detail:
4 ppm 4 hr
Method:
HPLC-Rad
Authors-red:
Hayton WL (1997b)
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