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U.S. Department of Health and Human Services

PhishPharm - Detail
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Title:  Total residue depletion and metabolic profile of selected drugs in salmonids: 17±-Methyltestosterone.
 
Authors:  Hayton WL (1997c)
 
Drug:  Methyltestosterone
 
Fish species:  Trout, rainbow
 
Date:  1997
 
Sample:  liver
 
Ave Weight (gm):  370
 
Ave Water temp (°C):  12
 
Water:  Freshwater
 
Dosage:  30 mg/kg SID 2 or 4 d
 
Route:  PO
 
Comments:  Residue by day 2 of treatment was liver 29.3 ppm. Values after 4 days feeding were slightly lower. Depuration was fastest from bile, followed by liver, muscle, kidney, plasma, and skin; Methyltestosterone (17±) (14C).
 
Metabolites:  Hydroxymethlytestosterone (HMT), unidentified metabolites.
 
Citation:  Final FDA Report. Contract 223-93-7014. Vol 2.
 
Link:  none  Opens a new window
 
Genus Species:  Oncorhynchus mykiss
 
Drug Class:  Hormone-Testosterone
 
Wt gm-detail:  370 +/- 73.6 g
 
Water temp (°C)-detail:  12 C
 
Dosage-detail:  30 mg/kg once a day for 2 or 4 days
 
Method:  HPLC-Rad
 
Authors-red:  Hayton WL (1997c)
 
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