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U.S. Department of Health and Human Services

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Title:  Effects of temperature on the loss of benzocaine and acetylated benzocaine residues from edible tissues of channel catfish Ictalurus punctatus.
 
Authors:  Stehly GR, Meinertz JP, Gingerich WH, Mazik PM, Gaikowski MP
 
Drug:  Benzocaine
 
Fish species:  Catfish, channel
 
Date:  1995
 
Sample:  muscle
 
Ave Weight (gm):  570
 
Ave Water temp (°C):  16
 
Water:  Freshwater
 
Dosage:  see comments
 
Route:  BATH
 
Comments:  Dose-70 mg/L for 5 min, then 35 mg/L for 30 min, the conclusion was that the rate of loss of benzocaine and acetylated benzocaine from fillets was not dependant on temperature (16 or 25); benzocaine concentrations were near or below the limit of quantitation by 12 h after exposure, see chart on pg 34, Benzocaine levels ng/g - 0h=29633 , Depuration - 1 h= 10593, 12 h = 13. Acetylated Benzocaine ng/g - 0h=946, Depuration 1 h=1230, 12 h=17. Benzocaine (14C). Appears to have a tri-phasic depletion.
 
Metabolites:  Acetylated benzocaine
 
Citation:  Final FDA Report. Contract 224-92-7036. Study CAP-94-00078-01
 
Link:  none  Opens a new window
 
Genus Species:  Ictalurus punctatus
 
Drug Class:  Anesthetic-Benzocaine
 
Wt gm-detail:  240-1580 gm kg
 
Water temp (°C)-detail:  16 C
 
Dosage-detail:  70 mg/L for 5 min, then 35 mg/L for 30 min
 
Method:  HPLC
 
Authors-red:  Stehly GR, Meinertz JP, Gingerich WH, Mazik PM, Gaikowski MP
 
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