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U.S. Department of Health and Human Services

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Title:  Comparative pharmacokinetics and bioavailability of oxytetracycline in giant tiger prawn.
 
Authors:  Sangrungruang K, Chotchuang A, Ueno R
 
Drug:  Oxytetracycline
 
Fish species:  Shrimp, giant tiger prawn (black tiger)
 
Date:  2004
 
t1/2-hr:  23
 
Sample:  blood, hemolymph
 
Ave Weight (gm):  24
 
Ave Water temp (°C):  30
 
Water:  Saltwater
 
Dosage:  10 mg/kg sd
 
Route:  IS
 
Comments:  ± = 0.74 per hour, ² = 0.03 per hour, Ke = 0.06 per hour, K12 = 0.35 per hour K21 = 0.34 per hour, T1/2 ± = 0.89 h, AUC = 760 ug/h/mL, AUC/dose = 76, MRT = 29.4 h. Cmax = 41.6 ug/ml, 10.9 ug/ml d2.
 
Cl:  0.0132 L/kg/h
 
Vc:  0.20 L/kg
 
Vd:  0.41 L/kg
 
Citation:  Fisheries Science 70:467-472
 
Link:  http://dx.doi.org/10.1111/j.1444-2906.2004.00827.x  Opens a new window
 
Genus Species:  Penaeus monodon
 
Drug Class:  Antibiotic-Tetracycline
 
t1/2-detail:  23.1 h
 
Wt gm-detail:  23.6 g
 
Water temp (°C)-detail:  30 C
 
Dosage-detail:  10 mg/kg sd
 
Method:  HPLC
 
Authors-red:  Sangrungruang K, Chotchuang A, Ueno R
 
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