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U.S. Department of Health and Human Services

PhishPharm - Detail
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Title:  Involement of multiple biotranformation processes in the metabolic elimination of testosterone by juvenile and adult fathead minnows (Pimephales promelas).
 
Authors:  Parks LG, LeBlanc GA
 
Drug:  Testosterone
 
Fish species:  Minnow, fathead
 
Date:  1998
 
t1/2-hr:  2
 
est:  est
 
Sample:  whole body
 
Ave Water temp (°C):  23
 
Water:  Freshwater
 
Dosage:  1.0 uM up to 4h
 
Route:  BATH
 
Comments:  (14C)-Testosterone. Juveniles accumualte max 100,000 nmol/g by 2h. Adult males max 12,000 by 2h. Adult females eliminated androstanediols at greater rate than males and juveniles eliminated nearly all metabolites at a greater rate than adults. Androstanediols Cl adult males-200 pmol/h/g.
 
Cl:  200 pmol/h/g
 
Metabolites:  Androstenedione, DHT, 3-Androstanediol (alpha &beta), 11-ketotestosterone, hydroxytestosterone(6 beta and 16 beta), Androstenetriols, conjugated forms.
 
Citation:  Genearal and Comparative Endocrinology 112:69-79
 
Link:  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9748405&query_hl=13  Opens a new window
 
Genus Species:  Pimephales promelas
 
Drug Class:  Hormone-Testosterone
 
t1/2-detail:  < 2h from graph
 
Wt gm-detail:  adults and juveniles-2-3 months
 
Water temp (°C)-detail:  22-23 C
 
Dosage-detail:  1.0 uM up to 4h
 
Method:  GC/MS, Rad, TLC
 
Authors-red:  Parks LG, LeBlanc GA
 
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