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U.S. Department of Health and Human Services

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Title:  Simultaneous determination of microcystin-LR and its glutathione conjugate in fish tissues by liquid chromatography-tandem mass spectrometry.
 
Authors:  Dai M, Xie P, Liang G, Chen J, Lei H
 
Drug:  Microcystin
 
Fish species:  Carp, crucian (goldfish)
 
Date:  2008
 
Sample:  liver
 
Ave Weight (gm):  265
 
Ave Water temp (°C):  0
 
Water:  Freshwater
 
Dosage:  100 ug/kg sd
 
Route:  IP
 
Comments:  Residues ug/g 1h=0.59, 3h=0.43, 12h=0.45, 24=0.25, 48=0.2, Cmax=0.59 at 1h concentration of glutathione congugate ug/g 1h, 3h, 12,and 48h = approx 0.03, conjugate Cmax 0.083 at 24h. Residues estimated from graph.
 
Metabolites:  Microcystin-glutathion conjugate
 
Citation:  J Chromatography B 862:43-50.
 
Link:  http://www.ncbi.nlm.nih.gov/pubmed/18093885?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum  Opens a new window
 
Genus Species:  Carassius auratus auratus
 
Drug Class:  Organic-Cyanotoxin
 
Wt gm-detail:  265+/-22.6
 
Water temp (°C)-detail:  Not Specified
 
Dosage-detail:  100 ug/kg sd
 
Method:  HPLC-MS
 
Authors-red:  Dai M, Xie P, Liang G, Chen J, Lei H
 
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