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U.S. Department of Health and Human Services

PhishPharm - Detail
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Title:  2,4-Dichlorophenoxyacetic acid disposition after oral administration in channel catfish.
 
Authors:  Plakas SM, Khoo L, Barron MG
 
Drug:  DCPA-(2,4-Dichlorophenoxyacetic acid)
 
Fish species:  Catfish, channel
 
Date:  1992
 
t1/2-hr:  1
 
Sample:  blood, plasma
 
Ave Weight (gm):  700
 
Ave Water temp (°C):  22
 
Water:  Freshwater
 
Dosage:  10 mg/kg sd
 
Route:  IVC
 
Comments:  t1/2 of distribution phase is 0.05 h; plasma protein binding values declined from 87% to 54% as the spiked plasma concentration was increased from 2.5 to 800 ppm; Vd= 167 ml/kg, Vc= 49 l/kg, CL-total body= 203 ml/kg/h, intercompartmental= 344 ml/kg/h. (14C) DCPA.
 
Cl:  0.203 L/kg/h*
 
Vc:  0.049 L/kg
 
Vd:  0.167 L/kg
 
Metabolites:  Unidentified polar metabolite
 
Citation:  J. Agricultural and Food Chemistry 40:1236-1239
 
Link:  http://pubs.acs.org/doi/abs/10.1021/jf00019a032  Opens a new window
 
Genus Species:  Ictalurus punctatus
 
Drug Class:  Organic-Chlorinated-Pesticide
 
t1/2-detail:  0.76 h
 
Wt gm-detail:  0.5-0.9 kg
 
Water temp (°C)-detail:  22 C
 
Dosage-detail:  10 mg/kg sd
 
Method:  HPLC-Rad
 
Authors-red:  Plakas SM, Khoo L, Barron MG
 
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