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U.S. Department of Health and Human Services

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Title:  Astaxanthin and Canthaxanthin kinetics after ingestion of individual doses by immature rainbow trout Oncorhynchus mykiss.
 
Authors:  Gobantes I, Choubert G, Laurentie M, Milicua JCG, Gomez R
 
Drug:  Canthaxanthin
 
Fish species:  Trout, rainbow
 
Date:  1997
 
t1/2-hr:  13
 
Sample:  blood, serum
 
Ave Weight (gm):  300
 
Ave Water temp (°C):  20
 
Water:  Freshwater
 
Dosage:  100 ug sd
 
Route:  PO
 
Comments:  Of 234 fish dosed, 5 did not show a serum response to carotenoid pigments. Max 2.9 nmol/ml 12 h post dose. Rapid decrease in residue between 12-42 hr. 42 h- near baseline residue. (0-0.5 nmol/ml). Mean retention time=23.1 h. AUC 52.9 ug h/ ml. Only detected in intestin up to 12 hrs (0.3 nmol/gm), not detected in liver.
 
Citation:  J. Agricultural and Food Chemistry 45:454-458
 
Link:  http://pubs.acs.org/cgi-bin/abstract.cgi/jafcau/1997/45/i02/abs/jf9604605.html  Opens a new window
 
Genus Species:  Oncorhynchus mykiss
 
Drug Class:  Organic-Carotenoid
 
t1/2-detail:  12.63 h
 
Wt gm-detail:  300 g
 
Water temp (°C)-detail:  20+/-0.5 C
 
Dosage-detail:  100 ug 5% water-sol beadlets in meal-sd
 
Method:  HPLC
 
Authors-red:  Gobantes I, Choubert G, Laurentie M, Milicua JCG, Gomez R
 
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