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U.S. Department of Health and Human Services

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Title:  Bioconcentration and elimination of sulfamethazine and its main metabolite in sturgeon (Acipenser schrenkii)
 
Authors:  Hou X, Shen J, Zhang S, Jiang H, Coats JR
 
Drug:  Sulfamethazine
 
Fish species:  Sturgeon, amur
 
Date:  2003
 
t1/2-hr:  24
 
Sample:  muscle
 
Ave Weight (gm):  28
 
Ave Water temp (°C):  20
 
Water:  Freshwater
 
Dosage:  0.10 mg/L 8 d
 
Route:  BATH
 
Comments:  BCF=1.19,relatively higher than the BCF at the 1.00 mg/L dose. uptake rate=20.16/h, elim rateK=16.8/h, Cmax aprox 0.15 mg/kg. 90% of the drug was eliminated within 3-4 days. No metabolite residue detected.
 
Metabolites:  N4-acetyl-SM2
 
Citation:  J. Agricultural and Food Chemistry 51:7725-7729
 
Dep-time:  approx 5 d
 
Link:  http://pubs.acs.org/cgi-bin/article.cgi/jafcau/2003/51/i26/pdf/jf030492+.pdf  Opens a new window
 
Genus Species:  Acipenser schrenckii
 
Drug Class:  Antibiotic-Sulfa
 
t1/2-detail:  23.52 h,
 
Wt gm-detail:  28.2 +/- 5.1
 
Water temp (°C)-detail:  19-20 °C
 
Dosage-detail:  0.10 mg/L 8 d
 
Method:  HPLC
 
Authors-red:  Hou X, Shen J, Zhang S, Jiang H, Coats JR
 
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