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U.S. Department of Health and Human Services

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Title:  Tissue distribution, metabolism, and residue depletion study in Atlantic salmon following oral administration of [3H]Emamectin Benzoate.
 
Authors:  Kim-Kang H, Bova A, Crouch LS, Wislocki PG, Robinson RA, Wu J
 
Drug:  Emamectin
 
Fish species:  Salmon, Atlantic
 
Date:  2004
 
t1/2-hr:  1440
 
est:  est
 
Sample:  muscle+skin
 
Ave Weight (gm):  1300
 
Ave Water temp (°C):  5
 
Water:  Saltwater
 
Dosage:  50 ug/kg 7 d
 
Route:  PO
 
Comments:  Total Radioactive Residue (3H) Emamectin 0.020+/-0.006 ppm at day 90. Residue 3h= 0.06, 12h= 0.062, d1= 0.055, d3=0.064, d7= 0.029, d15= 0.055, d30= 0.067, d45= 0.035, d60=0.027, d90=0.0196 ug/g. t1/2 est from graph.
 
Metabolites:  7 N-desmethylemamectin, 11 N-formylemamectin
 
Citation:  J. Agricultural Food Chemistry 52:2108-2118
 
Link:  http://pubs.acs.org/cgi-bin/abstract.cgi/jafcau/2004/52/i07/abs/jf035435v.html  Opens a new window
 
Genus Species:  Salmo salar
 
Drug Class:  Antiparasitic-Avermectin
 
t1/2-detail:  1440 h est
 
Wt gm-detail:  1300 g
 
Water temp (°C)-detail:  5+/-1 C
 
Dosage-detail:  50 ug/kg for 7 d
 
Method:  HPLC-Rad
 
Authors-red:  Kim-Kang H, Bova A, Crouch LS, Wislocki PG, Robinson RA, Wu J
 
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